Alces Bioworks
Alces Bioworks has developed a protein design platform that can be used to create novel binders.
Small, designed proteins can be used like monoclonal antibodies, but they have several advantages
- You know their structure and how they bind to your target
- Designed and tested in weeks instead of months for a monoclonal antibody
Modular, so they can be attached to various reporter tags
Easy to express and purify, and highly stable
Humane, because animals are not used to make them
What do we mean by binders?
A binder is a protein that physically sticks to, or binds, another protein.
Technology
- We created a computational pipeline that efficiently designs small proteins that bind target proteins of interest.
- We can specify where on your target protein the designed protein should bind.
- These designer proteins can be made in E. coli, so they can be produced quickly and in high yields.
- Designed proteins tend to be very stable.
FAQ
Why are binders better than antibodies?
Custom-designed binder proteins offer a powerful alternative to traditional antibodies, with key advantages for researchers and biotech professionals:
- Designed in silico using advanced computational protein design, ensuring high specificity and performance.
- Produced in E. coli, enabling rapid, scalable, and cost-effective recombinant protein production.
- Structurally defined—our engineered proteins have known molecular structures because we designed them.
- Modular format—customizable with detection tags such as GFP, GST, His-tag, biotin, and others to meet your application needs.
Animal-friendly—no animals are used at any stage. We don’t need to immunize mice, rabbits, alpacas, or even moose!